Published January 1, 2020
| Version v1
Journal article
Open
Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of epsilon-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier
Creators
- 1. Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Camino Vera S-N, Valencia 46022, Spain
- 2. Inst Invest Sanitaria La Fe, Grp Acreditado Infecc Grave, Av Fernando Abril Martorell, Valencia 46026, Spain
- 3. Konya Tech Univ, Dept Chem Engn, TR-42250 Konya, Turkey
Description
In recent times, many approaches have been developed against drug resistant Gram-negative bacteria. However, low-cost high effective materials which could broaden the spectrum of antibiotics are still needed. In this study, enhancement of linezolid spectrum, normally active against Gram-positive bacteria, was aimed for Gram-negative bacteria growth inhibition. For this purpose, a silica xerogel prepared from a low-cost precursor is used as a drug carrier owing to the advantages of its mesoporous structure, suitable pore and particle size and ultralow density. The silica xerogel is loaded with linezolid and capped with epsilon-poly-l-lysine. The developed nano-formulation shows a marked antibacterial activity against to Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. In comparison to free linezolid and epsilon-poly-l-lysine, the material demonstrates a synergistic effect on killing for the three tested bacteria. The results show that silica xerogels can be used as a potential drug carrier and activity enhancer. This strategy could provide the improvement of antibacterial activity spectrum of antibacterial agents like linezolid and could represent a powerful alternative to overcome antibiotic resistance in a near future.
Files
bib-4bf49f50-96cd-4cf4-aa12-cea2bfb74c16.txt
Files
(304 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:eadcc3d7af29e518e92bfd640d252d4f
|
304 Bytes | Preview Download |