DBU-catalyzed, aromatization-oriented, regioselective domino synthesis of 2-aminopyrimidines from beta-dicarbonyl compounds, DMF-DMA, and cyanamide

A multicomponent domino synthesis has been developed for the preparation of 2-aminopyrimidines from beta-dicarbonyl compounds, N,N-dimethylformamide dimethyl acetal, and cyanamide. The protocol was used for the regioselective preparation of 4-amide/ester/ketone substituted 2-aminopyrimidines. Twelve 2-aminopyrimidines were isolated in good yields (56-93%).