Published January 1, 2020
| Version v1
Journal article
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Intracerebroventricularly injected nesfatin-1 activates central cyclooxygenase and lipoxygenase pathways
Creators
- 1. Uludag Univ, Fac Arts & Sci, Dept Mol Biol & Genet, TR-16059 Bursa, Turkey
- 2. Uludag Univ, Fac Vet Med, Dept Histol & Embryol, TR-16059 Bursa, Turkey
- 3. Uludag Univ, Fac Vet Med, Dept Biochem, TR-16059 Bursa, Turkey
- 4. Uludag Univ, Fac Med, Dept Med Pharmacol, TR-16059 Bursa, Turkey
- 5. Uludag Univ, Fac Vet Med, Dept Physiol, TR-16059 Bursa, Turkey
Description
Nesfatin-1 is a multifunctional neuropeptide having crucial autonomic roles. It is well known that nesfatin-1 collaborates with other central neuromodulatory systems, such as central corticotropin-releasing hormone, melanocortin, oxytocin, and cholinergic systems to show its autonomic effects. Central arachidonic acid cascade plays an important role to provide the homeostasis by exhibiting similar autonomic effects to nesfatin-1. Based on these similarities, the current study was designed to show the effects of intracerebroventricularly (ICV) injected nesfatin-1 on the hypothalamic arachidonic acid (AA) cascade.
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