Published January 1, 2017
| Version v1
Journal article
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Deletion of the hfsB gene increases ethanol production in Thermoanaerobacterium saccharolyticum and several other thermophilic anaerobic bacteria
Creators
- 1. Recep Tayyip Erdogan Univ, Dept Biol, Mol Biol Res Labs, Fac Art & Sci, Rize, Turkey
- 2. Mascoma Corp, Lebanon, NH USA
- 3. Karadeniz Tech Univ, Fac Sci, Dept Biol, Trabzon, Turkey
Description
Background: With the discovery of interspecies hydrogen transfer in the late 1960s (Bryant et al. in Arch Microbiol 59:20-31, 1967), it was shown that reducing the partial pressure of hydrogen could cause mixed acid fermenting organisms to produce acetate at the expense of ethanol. Hydrogen and ethanol are both more reduced than glucose. Thus there is a tradeoff between production of these compounds imposed by electron balancing requirements; however, the mechanism is not fully known.
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