Published January 1, 2017
| Version v1
Journal article
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Chiral phosphinites as efficient ligands for enantioselective Ru(II), Rh(I) and Ir(III)-catalyzed transfer hydrogenation reactions
Creators
- 1. Dicle Univ, Sci Fac, Dept Chem, TR-21280 Diyarbakir, Turkey
- 2. Siirt Univ, Sci & Technol Applicat & Res Ctr SUBTAM, TR-56000 Siirt, Turkey
Description
Metal-catalyzed enantioselective transfer reduction of ketones to enantiomerically enriched chiral alcohols has recently attracted attention. Therefore, a series of methyl alkyl or alkyl/aryl ketones have been reduced by using Ru(II), Rh(I) and Ir(III) catalysts based on C (2)-symmetric chiral ferrocenyl phosphinite ligands. The corresponding optically active secondary alcohols were obtained in excellent conversions and moderate-to-good enantioselectivities. The best results were obtained with an iridium catalyst, giving up to 98% conversion and 80% ee.
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