Published January 1, 2009 | Version v1
Journal article Open

Regioselective synthesis of the 3,4-dihydrofuro[3,2-d]pyrimidin-2(1H)-one skeleton: a new class of compound

  • 1. Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey
  • 2. Ataturk Univ, Dept Chem, TR-25240 Erzurum, Turkey

Description

We hereby report the first preparation of the 3,4-dihydrofuro[3,2-d]pyrimidin-2(1H)-one skeleton formed by two controlled Curtius rearrangements of the corresponding acyl azides, prepared from 2-(2-methoxy-2-oxoethyl)furan-3-carboxylate via the hydrazide. Rearrangement of the acyl azides followed by trapping by nucleophiles and intramolecular trapping provided the target compounds. (C) 2009 Elsevier Ltd. All rights reserved.

Files

bib-ebb03716-256d-413a-8181-3a7ded12f1ab.txt

Files (191 Bytes)

Name Size Download all
md5:fb9e5f7623d94e8ea039aa92b2be7720
191 Bytes Preview Download