Diterpenoids from Sideritis tmolea P. H. Davis

Four known ent-kaurene diterpenoids 1-4 were isolated from the acetone extract of Sideritis tmolea P. H. Davis by using different chromatographic methods. The structures of the isolated compounds were determined as siderol (ent-7 alpha-acetoxy-18-hydroxy-kaur-15-ene) (1), 7-acetoxysideroxol (ent-7 alpha-acetoxy-18-hydroxy- 15 beta, 16 beta-epoxykaurane) ( 2), ent-7 alpha, 15 beta, 18-trihydroxykaur-16-ene (3) and ent-7 alpha-acetoxy-15 beta, 18-dihydroxykaur-16-ene (4) by using IR, NMR ((1)H, (13)C, APT and DEPT) techniques and mass spectroscopy. The antimicrobial and antituberculous activities of the acetone and methanol extracts and compound 1 have been reported.