Published January 1, 2009
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Catalytic Intermolecular Aldehyde-Ketone Coupling via Acyl Phosphonates
- 1. Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey
Description
The first catalytic intermolecular aldehyde-ketone coupling via acyl phosphonate is reported. Acyl phosphonates are potent acyl anion precursors, which generate acyl anion equivalents under the influence of cyanide anion via phosphonate-phosphate rearrangement. These anions readily react with activated ketones to form acyloin type coupling in 41-95% yields.
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