Published January 1, 2008 | Version v1
Journal article Open

Extracellularly signal-regulated kinase activity in the human endometrium: Possible roles in the pathogenesis of endometriosis

  • 1. Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA
  • 2. Ankara Univ, Sch Med, Dept Obstet & Gynecol, TR-06100 Ankara, Turkey
  • 3. Ankara Univ, Sch Med, Dept Pathol, TR-06100 Ankara, Turkey

Description

Context: Endometriosis is an estrogen-dependent disease characterized by the presence of endometrial tissue outside of the uterine cavity, causing pelvic pain and infertility in 10% of reproductive-aged women. It is unclear why ectopic endometrium remains viable in only a subset of women. ERK1/2 plays key intracellular roles in activating cellular survival and differentiation processes.

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