Published January 1, 2008
| Version v1
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Protective action of doxycycline against diabetic cardiomyopathy in rats
Creators
- 1. Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey
- 2. Ankara Univ, Dept Pharmacol, Fac Pharm, TR-06100 Ankara, Turkey
Description
Background and purpose: Reactive oxygen and nitrogen species play an important role in the development of diabetic cardiomyopathy. They can activate matrix metalloproteinases (MMPs), and MMP-2 in particular is known to mediate early consequences of oxidative stress injury in the heart. Therefore, we investigated the role of MMP-2 and the effect of the MMP inhibitor doxycycline on the changes of heart function caused by diabetes.
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