Yayınlanmış 1 Ocak 2008 | Sürüm v1
Dergi makalesi Açık

Protective action of doxycycline against diabetic cardiomyopathy in rats

  • 1. Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey
  • 2. Ankara Univ, Dept Pharmacol, Fac Pharm, TR-06100 Ankara, Turkey

Açıklama

Background and purpose: Reactive oxygen and nitrogen species play an important role in the development of diabetic cardiomyopathy. They can activate matrix metalloproteinases (MMPs), and MMP-2 in particular is known to mediate early consequences of oxidative stress injury in the heart. Therefore, we investigated the role of MMP-2 and the effect of the MMP inhibitor doxycycline on the changes of heart function caused by diabetes.

Dosyalar

bib-203e2e98-cfa9-4e5b-983f-93619973d269.txt

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md5:a82e7ef138833db76f0019b1c6bd7038
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