Published January 1, 2009
| Version v1
Journal article
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Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus
- 1. Univ Haute Alsace, CNRS, LRC 7228, Inst Sci Mat Mulhouse, F-68057 Mulhouse, France
- 2. BIOMAT, Dept Biol Sci, METU, Biotechnol Res Unit, TR-06531 Ankara, Turkey
- 3. Univ Freiburg, Inst Phys, D-79104 Freiburg, Germany
Description
Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer-sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.
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