Published January 1, 2009
| Version v1
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Reduction of Amphotericin B-Induced Renal Tubular Apoptosis by N-Acetylcysteine
- 1. Marmara Univ, Sch Med, Istanbul, Turkey
- 2. Etimesgut Mil Hosp, Ankara, Turkey
- 3. Univ Texas Houston, Sch Med, Houston, TX USA
Description
The reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-acetylcysteine (NAC) in a murine model was evaluated. Four groups of rats were treated with AmB for 5 days, and each group concomitantly received two doses of 30, 60, or 120 mg of NAC/kg of body weight/day or sterile water for 5 days. Groups that received concomitant NAC at any dose had significantly decreased levels of apoptosis compared to that in animals receiving AmB only (48.8% versus 27.4, 23.6, or 23.5%, respectively; P < 0.001).
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