Published January 1, 2009
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Serial changes in circulating M30 antigen, a biomarker of apoptosis, in patients with acute coronary syndromes: relationship with the severity of coronary artery disease
Creators
- 1. Uludag Univ, Sch Med, Dept Cardiol, TR-16059 Bursa, Turkey
- 2. Uludag Univ, Sch Med, Dept Internal Med, TR-16059 Bursa, Turkey
- 3. Uludag Univ, Sch Med, Dept Biochem, TR-16059 Bursa, Turkey
Description
Objectives Growing evidence has indicated the potential clinical usefulness of measuring different forms of cytokeratin 18 in patient sera (M30 antigen for apoptosis and M65 antigen for necrosis) for distinguishing different forms of cell death. Preliminary data have reported altered levels of cytokeratin 18 fragments in patients with acute coronary syndrome (ACS) and ischemic heart disease. In this study, serum levels of M30 and M65 were measured in 74 patients with ACS [including 17 cases with unstable angina and 57 patients with acute myocardial infarction (AMI)], 25 patients with stable angina, and 23 controls.
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