Yayınlanmış 1 Ocak 2009
| Sürüm v1
Dergi makalesi
Açık
A LRRK2 G2019S mutation carrier from Turkey shares the Japanese haplotype
Oluşturanlar
- 1. Bogazici Univ, Dept Mol Biol & Genet, Neurodegenerat Res Lab, TR-34342 Istanbul, Turkey
- 2. Juntendo Univ, Sch Med, Dept Neurol, Tokyo 113, Japan
- 3. Univ Istanbul, Dept Neurol, Cerrahpasa Fac Med, TR-34098 Istanbul, Turkey
Açıklama
The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is recognized as the most common cause of familial autosomal dominant and also sporadic forms of Parkinson disease (PD). A common founder has been described for most Europeans and all North Africans and Jews; besides, two distinct G2019S LRRK2 haplotypes were found in a small proportion of European families and in Japanese PD patients. This study revealed a Turkish patient heterozygous for the G2019S mutation sharing the Japanese haplotype. To the best of our knowledge, it is the first time that the G2019S-associated Japanese haplotype has been reported in a different population.
Dosyalar
bib-2d687bba-9ad9-40d8-9f6f-b84094e7dc7a.txt
Dosyalar
(213 Bytes)
| Ad | Boyut | Hepisini indir |
|---|---|---|
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md5:f8a2dc3cb79abbaa549729ead7e51dbe
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213 Bytes | Ön İzleme İndir |