Published January 1, 2009
| Version v1
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A LRRK2 G2019S mutation carrier from Turkey shares the Japanese haplotype
Creators
- 1. Bogazici Univ, Dept Mol Biol & Genet, Neurodegenerat Res Lab, TR-34342 Istanbul, Turkey
- 2. Juntendo Univ, Sch Med, Dept Neurol, Tokyo 113, Japan
- 3. Univ Istanbul, Dept Neurol, Cerrahpasa Fac Med, TR-34098 Istanbul, Turkey
Description
The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is recognized as the most common cause of familial autosomal dominant and also sporadic forms of Parkinson disease (PD). A common founder has been described for most Europeans and all North Africans and Jews; besides, two distinct G2019S LRRK2 haplotypes were found in a small proportion of European families and in Japanese PD patients. This study revealed a Turkish patient heterozygous for the G2019S mutation sharing the Japanese haplotype. To the best of our knowledge, it is the first time that the G2019S-associated Japanese haplotype has been reported in a different population.
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