Published January 1, 2009 | Version v1
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Mitochondrial Respiratory Chain Enzyme Activities, mtDNA Variants and Gene Expression Levels in Idiopathic Parkinson's Disease

  • 1. Hacettepe Univ, Fac Pharm, Dept Biochem, TR-06100 Ankara, Turkey
  • 2. Hacettepe Univ, Fac Med, Dept Biochem, TR-06100 Ankara, Turkey
  • 3. Ankara Res & Training Hosp, Dept Neurol, TR-06100 Ankara, Turkey

Description

Purpose: Mitochondrial dysfunction has been implicated in the development of idiopathic Parkinson's disease. In this study, it was aimed to investigate the relationship between mitochondrial respiratory chain enzyme deficiency and variants in ND2 and ND4 region of Complex I and expressions of these genes. Complex IV activity and glutathione level were also studied.

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