Yayınlanmış 1 Ocak 2008 | Sürüm v1
Dergi makalesi Açık

Carbon monoxide-prostaglandin E-2 interaction in the hypothalamic circulation

  • 1. Semmelweis Univ, Inst Human Physiol & Clin Expt Res, H-1446 Budapest, Hungary
  • 2. Univ Marburg, Dept Pediat, Marburg, Germany
  • 3. Semmelweis Univ, Dept Med Chem Mol Biol & Pathobiochem, H-1446 Budapest, Hungary

Açıklama

The heme oxygenase (HO)-carbon monoxide pathway was earlier shown to increase hypothalamic blood flow after inhibition of nitric oxide synthesis in rats. We hypothesized that this effect is mediated by prostaglandin E-2 (PGE(2)). Inhibition of constitutive HO activity decreased cerebral PGE2 production and simultaneously increased hypothalamic nitric oxide synthase (NOS) activity without changing hypothalamic blood flow. Furthermore, HO blockade induced cyclooxygenase-dependent decrease and NOS-mediated increase of the hypothalamic blood flow after inhibition of NOS and cyclooxygenase, respectively. Therefore, constitutive carbon monoxide release seems to have two indirect effects on the hypothalamic circulation: vasodilation mediated by PGE2 and vasoconstriction as a result of NOS inhibition. NeuroReport 19:1601-1604 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.

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