Yayınlanmış 1 Ocak 2003 | Sürüm v1
Dergi makalesi Açık

Decreased expression of beta(1)- and beta(2)-adrenoceptors in human diabetic atrial appendage

  • 1. Ankara Univ, Fac Pharm, Dept Pharmacol, TR-06100 Ankara, Turkey
  • 2. Baskent Univ, Sch Med, Dept Cardiovasc Surg, TR-06490 Ankara, Turkey
  • 3. Univ Nebraska Med Ctr, Dept Pharmacol, Omaha, NE USA

Açıklama

Background: Using the streptozotocin-induced diabetic rat model, we have recently showed that the expression and function of beta(1)-adrenoreceptor were decreased in the diabetic rat heart. However, the effect of diabetes on expression of beta-adrenoreceptors in human cardiac tissue remains undefined. Therefore, the focus of the present study was to investigate the effect of diabetes on mRNA encoding beta(1)- and beta(2)-ARs in human atrial tissues.

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