Published January 1, 2003
| Version v1
Journal article
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Decreased expression of beta(1)- and beta(2)-adrenoceptors in human diabetic atrial appendage
Creators
- 1. Ankara Univ, Fac Pharm, Dept Pharmacol, TR-06100 Ankara, Turkey
- 2. Baskent Univ, Sch Med, Dept Cardiovasc Surg, TR-06490 Ankara, Turkey
- 3. Univ Nebraska Med Ctr, Dept Pharmacol, Omaha, NE USA
Description
Background: Using the streptozotocin-induced diabetic rat model, we have recently showed that the expression and function of beta(1)-adrenoreceptor were decreased in the diabetic rat heart. However, the effect of diabetes on expression of beta-adrenoreceptors in human cardiac tissue remains undefined. Therefore, the focus of the present study was to investigate the effect of diabetes on mRNA encoding beta(1)- and beta(2)-ARs in human atrial tissues.
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