Published January 1, 2009 | Version v1
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Comparative analysis of IL6 promoter and receptor polymorphisms in myelodysplasia and multiple myeloma

  • 1. Semmelweis Univ, Dept Internal Med 3, H-1125 Budapest, Hungary
  • 2. Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1125 Budapest, Hungary

Description

The serum levels of interleukin 6 (IL6) are known to be elevated in two diseases of the elderly age, myelodysplastic syndrome (MDS) and multiple myeloma (MM). Authors suppose that one of the possible causes of this elevation could be a difference between these patients and healthy subjects in the frequency of polymorphic variants of the genes regulating IL6 levels. Scarce and contradictory comparative data are available for MM and to our best knowledge this is the first study on IL6 promoter and IL6 receptor (IL6R) polymorphism in MDS.

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