Published January 1, 2009
| Version v1
Journal article
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Increased Frequency of Extremely Skewed X Chromosome Inactivation in Juvenile Idiopathic Arthritis
Creators
- 1. Bilkent Univ, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey
- 2. Hacettepe Univ, Sch Med, Ankara, Turkey
- 3. Istanbul Univ, Cerrahpasa Fac Med, Istanbul, Turkey
Description
Objective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA.
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