Yayınlanmış 1 Ocak 2009
| Sürüm v1
Dergi makalesi
Açık
Increased Frequency of Extremely Skewed X Chromosome Inactivation in Juvenile Idiopathic Arthritis
Oluşturanlar
- 1. Bilkent Univ, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey
- 2. Hacettepe Univ, Sch Med, Ankara, Turkey
- 3. Istanbul Univ, Cerrahpasa Fac Med, Istanbul, Turkey
Açıklama
Objective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA.
Dosyalar
bib-b9dc9374-1803-42c2-9013-1f46fcef11a0.txt
Dosyalar
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