Published January 1, 2008
| Version v1
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Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice
Creators
- 1. Mersin Univ, Dept Pharmacol, Fac Med, TR-33169 Mersin, Turkey
Description
Background and purpose: Rho/Rho-kinase signalling is involved in many cellular events, including some in the CNS. However, the role of this pathway in epilepsy has not yet been assessed. Therefore, we determined the effects of two Rho-kinase inhibitors, Y-27632 and fasudil, on seizures induced by pentylenetetrazole (PTZ) or maximal electroconvulsive shock (MES).
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