Published January 1, 2008
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Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the In vivo Elimination of Methotrexate and its Main Toxic Metabolite 7-hydroxymethotrexate
Creators
- 1. Netherlands Canc Inst, Div Expt Therapy, NL-1066 CX Amsterdam, Netherlands
- 2. Istanbul Univ, Fac Pharm, Istanbul, Turkey
- 3. Netherlands Canc Inst, Div Clin Chem, NL-1066 CX Amsterdam, Netherlands
- 4. Univ Amsterdam, Acad Med Ctr, AMC Liver Ctr, NL-1105 AZ Amsterdam, Netherlands
- 5. Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands
Description
Purpose: ATP-binding cassette sub-family C member 2 [ABCC2; multidrug resistance associated protein 2 (MRP2)] and ABCC3 (MRP3) mediate the elimination of toxic compounds, such as drugs and carcinogens, and have a large overlap in substrate specificity. We investigated the roles of Abcc2 and Abcc3 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX) in vivo.
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