Synthesis and Potent Antifungal Activity Against Candida Species of Some Novel 1H-Benzimidazoles

A series of 47 novel N(1)-alkylated-2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 mu g/mL. Indole analogues 108-110 have no inhibitory activity.