Published January 1, 2018
| Version v1
Journal article
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Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis
- 1. Suleyman Demirel Univ, Dept Periodontol, Fac Dent, Isparta, Turkey
- 2. Mehmet Akif Ersoy Univ, Dept Pathol, Fac Vet Med, Burdur, Turkey
- 3. Mustafa Kemal Univ, Dept Periodontol, Fac Dent, Antakya, Turkey
- 4. Private Elitia Oral & Dent Hlth Polyclin, Alanya Antalya, Turkey
- 5. Private Clin, Bolu, Turkey
Description
Background and Objective: Nitric oxide is a free radical that is synthesized from L-arginine by nitric oxide synthase (NOS). The level of inducible NOS (iNOS) in gingiva with periodontitis is higher than that in healthy gingiva. The aim of this study was to evaluate the effects of rosuvastatin administration on alveolar bone loss (ABL) and iNOS(+) cell counts in gingival tissues in rats with ligature-induced experimental periodontitis with/without hyperlipidaemia.
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