Published January 1, 2018
| Version v1
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Biotransformation of cyclocanthogenol by the endophytic fungus Alternaria eureka 1E1BL1
Creators
- 1. Near East Univ, Fac Pharm, Dept Pharmacognosy, Mersin 10, Nicosia, Turkey
- 2. Izmir Inst Technol, Fac Engn, Dept Bioengn, TR-35430 Urla Izmir, Turkey
Description
The microbial transformation of cyclocanthogenol (CCG), Astragalus sp. originated sapogenin, by the endophytic fungus Alternaria eureka 1E1BL1 isolated from Astragalus angustifolius was investigated. Hydroxylation, oxidation, epoxidation, O-methylation, ring-expansion and methyl migration reactions were observed on the triterpenoid skeleton. As a result, eight metabolites were isolated and the structures of the previously undescribed compounds were established by 1-D, 2-D NMR and HR-MS analyses. (C) 2018 Elsevier Ltd. All rights reserved.
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