Yayınlanmış 1 Ocak 2018
| Sürüm v1
Dergi makalesi
Açık
A highly collateralized thalamic cell type with arousal-predicting activity serves as a key hub for graded state transitions in the forebrain
Oluşturanlar
- 1. Hungarian Acad Sci, Inst Expt Med, Dept Cellular & Network Neurobiol, Budapest, Hungary
- 2. Univ Autonoma Madrid, Sch Med, Dept Anat & Neurosci, Brain Connect Lab, Madrid, Spain
- 3. Szent Borbala Hosp, Dept Pathol, Tatabanya, Hungary
Açıklama
Sleep cycles consist of rapid alterations between arousal states, including transient perturbation of sleep rhythms, microarousals, and full-blown awake states. Here we demonstrate that the calretinin (CR)-containing neurons in the dorsal medial thalamus (DMT) constitute a key diencephalic node that mediates distinct levels of forebrain arousal. Cell-type-specific activation of DMT/CR+ cells elicited active locomotion lasting for minutes, stereotyped microarousals, or transient disruption of sleep rhythms, depending on the parameters of the stimulation. State transitions could be induced in both slow-wave and rapid eye-movement sleep. The DMT/CR+ cells displayed elevated activity before arousal, received selective subcortical inputs, and innervated several forebrain sites via highly branched axons. Together, these features enable DMT/CR+ cells to summate subcortical arousal information and effectively transfer it as a rapid, synchronous signal to several forebrain regions to modulate the level of arousal.
Dosyalar
bib-b5cd9e5a-1064-4d99-94a3-c2acede7cd53.txt
Dosyalar
(343 Bytes)
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