Published January 1, 2018
| Version v1
Journal article
Open
Potential effects of metformin in DNA BER system based on oxidative status in type 2 diabetes
Creators
- 1. Ufuk Univ, Med Biol Dept, TR-06520 Ankara, Turkey
- 2. Ufuk Univ, Med Biochem Dept, TR-06520 Ankara, Turkey
- 3. Ufuk Univ, Med Genet Dept, TR-06520 Ankara, Turkey
- 4. Ufuk Univ, Internal Med Dept, TR-06520 Ankara, Turkey
Description
Metformin is used to reduce hyperglycemia that induces energetic stress and leads to reduction in gluconeogenesis. Also, metformin inhibits complex I in oxidative phosphorylation, thereby decreasing cellular ATP levels. Activation of AMPK by the reduced ATP levels can induce inhibition of reactive oxygen species (ROS) production and activate p53-mediated DNA repair.
Files
bib-c6b6e6f5-cd97-4eb1-b3d2-20fa6f6836bd.txt
Files
(203 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:686d55c3fadc30ecc0398f778886efa5
|
203 Bytes | Preview Download |