Yayınlanmış 1 Ocak 2020 | Sürüm v1
Dergi makalesi Açık

Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation

  • 1. Natl & Kapodistrian Univ Athens, Dept Chem, Lab Organ Chem, Athens, Greece
  • 2. G DAnnunzio Univ Chieti Pescara, Dept Pharm, Via Vestini 31, I-66100 Chieti, CH, Italy
  • 3. Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, Erzurum, Turkey

Açıklama

To date, drugs that hit a single target are inadequate for the treatment of neurodegenerative diseases, such as Alzheimer's or Parkinson's diseases. The development of multitarget ligands, able to interact with the different pathways involved in the progession of these disorders, represents a great challenge for medicinal chemists.

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