Published January 1, 2020
| Version v1
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Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation
Creators
- 1. Natl & Kapodistrian Univ Athens, Dept Chem, Lab Organ Chem, Athens, Greece
- 2. G DAnnunzio Univ Chieti Pescara, Dept Pharm, Via Vestini 31, I-66100 Chieti, CH, Italy
- 3. Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, Erzurum, Turkey
Description
To date, drugs that hit a single target are inadequate for the treatment of neurodegenerative diseases, such as Alzheimer's or Parkinson's diseases. The development of multitarget ligands, able to interact with the different pathways involved in the progession of these disorders, represents a great challenge for medicinal chemists.
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