Yayınlanmış 1 Ocak 2018
| Sürüm v1
Dergi makalesi
Açık
Secretomes reveal several novel proteins as well as TGF-beta 1 as the top upstream regulator of metastatic process in breast cancer
Oluşturanlar
- 1. Akdeniz Univ, Sch Med, Dept Med Pharmacol, SBAUM Immunol Lab, B Blok Kat 1, Antalya, Turkey
- 2. Dumlupinar Univ, Sch Med, Dept Med Biol, Kutahya, Turkey
Açıklama
Metastatic breast cancer is resistant to many conventional treatments and novel therapeutic targets are needed. We previously isolated subsets of 4T1 murine breast cancer cells which metastasized to liver (4TLM), brain (4TBM), and heart (4THM). Among these cells, 4TLM is the most aggressive one, demonstrating mesenchymal phenotype. Here we compared secreted proteins from 4TLM, 4TBM, and 4THM cells and compared with that of hardly metastatic 67NR cells to detect differentially secreted factors involved in organ-specific metastasis.
Dosyalar
bib-cebdba15-bf81-48fb-b6b6-899c83bd60ba.txt
Dosyalar
(230 Bytes)
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md5:2a79a9eb56bbd25606a527f184422b99
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230 Bytes | Ön İzleme İndir |