Yayınlanmış 1 Ocak 2020
| Sürüm v1
Dergi makalesi
Açık
The treatment effect on peripheral B cell markers in antibody positive myasthenia gravis patients
Oluşturanlar
- 1. Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Neurosci, Istanbul, Turkey
- 2. Istanbul Univ, Istanbul Med Fac, Dept Neurol, Istanbul, Turkey
- 3. Bakirkoy Res & Training Hosp Psychiat & Neurol Di, Dept Neurol, Istanbul, Turkey
- 4. Demiroglu Bilim Univ, Sisli Florence Nightingale Hosp, Dept Neurol, Istanbul, Turkey
- 5. Istanbul Univ, Dept Physiol, Istanbul, Turkey
Açıklama
B cells play a major role in the pathophysiology of myasthenia gravis (MG) with their ability to produce disease specific, pathogenic antibodies. However, their status during disease development and follow-up stages of the disease in the peripheral blood may need further studies to determine useful markers. In this study, we aimed to detect B cell associated factors concerning immunosuppressive treatment in generalized non-thymomatous MG patients. Although CD19(+) B cell distribution did not vary among disease subgroups, expressions of both CD38 and BAFFR were altered on B cells in MG patients under immunosuppressive therapy. Serum levels of BAFF were elevated in untreated MG patients as compared to treated MG patients and healthy controls. B cell activation factors may show profound alterations due to immunosuppression.
Dosyalar
bib-f47bb2f0-c2f2-4427-aef1-ec1ce0a7f21b.txt
Dosyalar
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