Published January 1, 2018
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Photodynamic therapy and nuclear imaging activities of SubPhthalocyanine integrated TiO2 nanoparticles
Creators
- 1. Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, TR-35100 Izmir, Turkey
- 2. Mersin Univ, Adv Technol Res & Applicat Ctr, Ciftlikkoy Campus, TR-33343 Yenisehir, Mersin, Turkey
- 3. Mersin Univ, Dept Energy Syst Engn, Fac Tarsus Technol, TR-33480 Mersin, Turkey
- 4. Ege Univ, Inst Sci, Dept Biomed Technol, TR-35100 Izmir, Turkey
Description
In this study, Subphthalocyanine (SubPc) and SubPc integrated TiO2 nanoparticles (SubPc- TiO2) were examined as theranostic agents. In vitro photodynamic therapy (PDT) efficiency of SubPc/SubPc-TiO2 and nuclear imaging potential of I-131 labeled SubPc/TiO2-SubPc were determined on hepatocellular carcinoma (HepG2), colorectal adenocarcinoma (HT29) and human healthy lung (WI38) cell lines. As a result, I-131-SubPc and I-131-SubPc-TiO2 have been identified as a nuclear imaging agent for liver cancer. Additionally, I-131-SubPc-TiO2 has been found to be promising for imaging colon tumors. According to the in vitro photodynamic therapy studies, SubPc and SubPc-TiO2 were determined suitable PDT agents for liver and colon tumors. These results suggest that SubPc: TiO2 might be a theranostic agent with both PDT and nuclear imaging potential.
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