Published January 1, 2018
| Version v1
Journal article
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Protective Effects of Ursolic Acid in the Kidneys o Diabetic Rats
Creators
- 1. Hacettepe Unvers, Dept Pharmaceut Toxicol, Fac Pharm, Ankara, Turkey
- 2. Karadeniz Tech Univ, Fac Pharm, Dept Pharmaceut Toxicol, Trabzon, Turkey
- 3. Ankara Unvers, Dept Pharmacol, Fac Pharm, Ankara, Turkey
- 4. Hacettepe Unvers, Dept Pharmacognosy, Fac Pharm, Ankara, Turkey
Description
Objectives: Diabetes, a heteregenous metabolic and chronic disease, is a growing health problem in most countries. It has been claimed that diabetes is associated with the increased formation of free radicals and decreased in antioxidant potential. Oxidative stress formed in diabetes may cause DNA damage in the tissues. Ursolic acid, a well-known pentacylic triterpene, is commonly used in traditional Chinese medicine due to its beneficial health effects such as antioxidant, anticancer, and antiulcer properties. The aim of this study was to investigate the effects of ursolic acid in the kidneys of Wistar albino rats with streptozotocin-induced diabetes.
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