Published January 1, 2018
| Version v1
Journal article
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Discovering lncRNA mediated sponge interactions in breast cancer molecular subtypes
Creators
- 1. Bilkent Univ, Dept Comp Engn, TR-06800 Ankara, Turkey
- 2. Bilkent Univ, Fac Sci, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey
- 3. Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey
Description
Background: Long non-coding RNAs (lncRNAs) can indirectly regulate mRNAs expression levels by sequestering microRNAs (miRNAs), and act as competing endogenous RNAs (ceRNAs) or as sponges. Previous studies identified lncRNA-mediated sponge interactions in various cancers including the breast cancer. However, breast cancer subtypes are quite distinct in terms of their molecular profiles; therefore, ceRNAs are expected to be subtype-specific as well.
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