Yayınlanmış 1 Ocak 2018
| Sürüm v1
Dergi makalesi
Açık
Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4
Oluşturanlar
- 1. Kyoto Univ, Inst Frontier Life & Med Sci, Dept Virus Res, Lab Immune Regulat, Kyoto 6068507, Japan
- 2. Kyoto Univ, Inst Frontier Life & Med Sci, Reprod Engn Team, Kyoto 6068507, Japan
- 3. Kyushu Univ, Network Ctr Infect Dis, Med Inst Bioregulat, Div Host Def, Fukuoka 8128582, Japan
- 4. German Canc Res Ctr, Dept Mol Biol Cell 1, D-69120 Heidelberg, Germany
Açıklama
Glucocorticoids are steroid hormones with strong anti-inflammatory and immunosuppressive effects that are produced in a diurnal fashion. Although glucocorticoids have the potential to induce inter-leukin-7 receptor (IL-7R) expression in T cells, whether they control T cell homeostasis and responses at physiological concentrations remains unclear. We found that glucocorticoid receptor signaling induces IL-7R expression in mouse T cells by binding to an enhancer of the IL-7R alpha locus, with a peak at midnight and a trough at midday. This diurnal induction of IL-7R supported the survival of T cells and their redistribution between lymph nodes, spleen, and blood by controlling expression of the chemokine receptor CXCR4. In mice, T cell accumulation in the spleen at night enhanced immune responses against soluble antigens and systemic bacterial infection. Our results reveal the immunoenhancing role of glucocorticoids in adaptive immunity and provide insight into how immune function is regulated by the diurnal rhythm.
Dosyalar
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Dosyalar
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