Published January 1, 2018
| Version v1
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Influence of lipopolysaccharide on proinflammatory gene expression in human corneal, conjunctival and meibomian gland epithelial cells
Creators
- 1. Harvard Med Sch, Dept Ophthalmol, Massachusetts Eye & Ear, Schepens Eye Res Inst, Boston, MA USA
Description
Purpose: Lipopolysaccharide (LPS), a bacterial endotoxin, is known to stimulate leuokotriene B4 (LTB4) secretion by human corneal (HCECs), conjunctival (HConjECs) and meibomian gland (HMGECs) epithelial cells. We hypothesize that this LTB4 effect represents an overall induction of proinflammatory gene expression in these cells. Our objective was to test this hypothesis.
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