Citicoline modulates oxidative and mitochondrial stress-induced proteomic remodeling in SH-SY5Y cells

Supplementary Tables for: Citicoline modulates oxidative and mitochondrial stress-induced proteomic remodeling in SH-SY5Y cells

Supplementary Table S1. Viability of SH-SY5Y cells after 24 h treatment, measured by WST-1 assay. Values are expressed as a percentage of the untreated control (mean ± SD, n = 3).

Supplementary Table S2. Quantitative proteomic data and differential expression analysis. S2A: full 298-protein analysis set with log₂FC, p and FDR values for each treatment versus control; S2B–S2C: H₂O₂- and antimycin A-induced DEPs (|log₂FC| > 0.58, FDR < 0.05); S2D–S2F: DEPs for H₂O₂ + citicoline, antimycin A + citicoline and citicoline alone versus control; S2G–S2H: normalization/attenuation classification of H₂O₂- and antimycin A-induced DEPs; S2I: proteins altered under both stressors; S2J–S2K: Progenesis QIP protein and peptide identification and quantification output.

Supplementary Table S3. Complete Reactome pathway enrichment results (FDR < 0.05) for H₂O₂-induced DEPs (S3A), antimycin A-induced DEPs (S3B), and H₂O₂ (S3C) and antimycin A (S3D) DEPs normalized or attenuated by citicoline.