MSX2 is an ERα-associated transcription factor that sustains proliferative capacity and is associated with favorable prognosis in luminal breast cancer
Description
Supplementary Tables: MSX2 is an ERα-associated transcription factor that sustains proliferative capacity and is associated with favorable prognosis in luminal breast cancer
Supp Table 1. In silico off-target specificity analysis of sgRNAs used for CRISPR–Cas9-mediated gene disruption.
Supp Table 2. Significant_DEGs_Filtered_Normal VS Luminal: Differential gene expression analysis of luminal breast cancer versus normal breast epithelial cell lines.
Supp Table 3-1. Significant_DEGs_Filtered_gse126003: Differential gene expression analysis following ESR1 knockdown in luminal breast cancer cell lines.
Supp Table 3-2. Significant_DEGs_Filtered_gse152323: Differential gene expression analysis following ESR1 knockdown in luminal breast cancer cell lines.
Supp Table 4. GOEnrich_Downregulated_BP: Gene Ontology Biological Process enrichment analysis of commonly downregulated genes.
Supp Table 5. GOEnrich_Downregulated_MF: Gene Ontology Molecular Function enrichment analysis of commonly downregulated genes.
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Additional details
Dates
- Issued
-
2026-09
References
- GSE126003: Siersbæk R, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK (2020). IL6/STAT3 signaling hijacks estrogen receptor α enhancers to drive breast cancer metastasis. Cancer Cell 38(3): 412-423.e9. https://doi.org/10.1016/j.ccell.2020.06.007
- GSE152323: Lu X, Redon CE, Tang W, Parvathaneni S, Bokhari B et al. (2021). Genome-wide analysis unveils DNA helicase RECQ1 as a regulator of estrogen response pathway in breast cancer cells. Molecular and Cellular Biology 41(4): e00515-20. https://doi.org/10.1128/MCB.00515-20
- GSE48213: Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM et al. (2013). Modeling precision treatment of breast cancer. Genome Biology 14(10): R110. https://doi.org/10.1186/gb-2013-14-10-r110
- GSE73526: Marcotte R, Sayad A, Brown KR, Sanchez-Garcia F, Reimand J et al. (2016). Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance. Cell 164(1-2): 293-309. https://doi.org/10.1016/j.cell.2015.11.062
- RNA-seq data were obtained from the Gene Expression Omnibus (GEO) under accession number GSE152908.