Published January 1, 2020
| Version v1
Journal article
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Evaluation of T Lymphocyte Subgroups in Patients with Chronic Lymphocytic Leukemia
Creators
- 1. Istanbul Univ, Aziz Sancar Deneysel Tip Arastirma Enstitusu, Immunol Anabilim Dali, Istanbul 34393, Turkey
- 2. Istanbul Univ, Istanbul Tip Fak, Ic Hastaliklari Anabilim Dali, Hematol Bilim Dali, Istanbul, Turkey
Description
Introduction: Chronic lymphocytic leukemia (CLL) that arises by malignant transformation of mature B cell is the most common leukemia in elderly. CLL is characterized by accumulation of CD5(+)CD19(+) cells in the peripheral blood and lymphoid organs. While CD8(+) T lymphocytes response intracellular pathogen and tumor, CD4(+) T lymphocytes regulate immune response. T follicular (Tfol) cells stimulate affinity maturation and class-switch recombination in B lymphocytes due to cytokine and surface molecules. In this study, we aimed to investigate CD4(+)T, CD8(+)T and CD3(+)CD4(+)CXCR5(+) follicular T (Tfol) cells in the peripheral blood of the CLL patients compared to healthy controls.
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