Published January 1, 2018
| Version v1
Journal article
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Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line
Creators
- 1. Bezmialem Vakif Univ, Sch Med, Dept Med Biochem, TR-34093 Fatih Istanbul, Turkey
- 2. Yildiz Tech Univ, Fac Art & Sci, Dept Chem, TR-34220 Istanbul, Turkey
- 3. Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey
- 4. Bezmialem Vakif Univ, Fac Pharm, Dept Pharmacognosy & Phytochem, TR-34093 Fatih Istanbul, Turkey
Description
Background: Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by H-1- and C-13 NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were evaluated for their cytotoxic activity. They showed proliferative effect at low concentrations while cytotoxic effect was observed at high concentrations in a dose dependent manner.
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