Exploring The Therapeutic Potential of <i>Xanthoparmelia pulla</i> (Ach.) O. Blanco, A. Crespo, Elix, D. Hawksw. & Lumbsch (Parmeliaceae)
Creators
- 1. Yozgat Bozok Univ, Fac Sci, Dept Biol, Yozgat, Turkiye
- 2. Yozgat Bozok Univ, Bogazliyan Vocat Sch, Yozgat, Turkiye
- 3. Erciyes Univ, Fac Pharm, Kayseri, Turkiye
- 4. Kayseri Univ, Safiye Cikrikgioglu Vocat Sch, Kayseri, Turkiye
- 5. Erciyes Univ, Fac Sci, Dept Chem, Kayseri, Turkiye
Description
Aim of study: This study aims to investigate the antioxidant effect and potential toxicity of the methanol extract of X. pulla species in Turkey and to identify the secondary metabolites of this species. Area of study: Samples were collected from Yozgat Bozok University East Campus.
Material and method: Detection of secondary metabolites in X. pulla was performed using HPLC. Antioxidant activity was evaluated using DPPH center dot and ABTS(center dot+) methods. Cytotoxicity was evaluated using MTT assay in MCF-7 and MDA-MB-231 cell lines.
Main results: The highest secondary metabolite was salazinic acid (37.23 +/- 9.21 mg/extract). Total phenol content was 172.77 +/- 10.50 mg GAE/g and flavonoid content was 9.25 +/- 1.32 mg CA/g. The extract showed 87.41% DPPH center dot radical scavenging activity at 2 mg/mL concentration and effectively neutralized ABTS(center dot+) radical at all concentrations. In terms of cytotoxicity, MCF-7 cell viability was inhibited by 66.84% at 125 mu g/mL and MDA-MB-231 cell viability was inhibited by 39.42% at 250 mu g/mL.
Research highlights: This study reveals the biological activity of X. pulla and its potential for natural product based drug development.
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