Published January 1, 2018
| Version v1
Journal article
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Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems
Creators
- 1. Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA
- 2. Virginia Commonwealth Univ, Dept Psychol, VCU POB 842018,806 West Franklin St, Richmond, VA 23284 USA
- 3. Virginia Commonwealth Univ, Ctr Clin & Translat Res, Richmond, VA USA
- 4. Univ Helsinki, Inst Mol Med FIMM, Helsinki, Finland
- 5. Univ Jyvaskyla, Dept Psychol, Jyvaskyla, Finland
- 6. Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN USA
Description
BackgroundCharacterizing aggregate genetic risk for alcohol misuse and identifying variants involved in gene-by-environment (GxE) interaction effects has so far been a major challenge. We hypothesized that functional genomic information could be used to enhance detection of polygenic signal underlying alcohol misuse and to prioritize identification of single nucleotide polymorphisms (SNPs) most likely to exhibit GxE effects.
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