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Published January 1, 2025 | Version v1
Journal article Open

Carbon Monoxide in an Experimental Model of Chronic Pelvic Pain Syndrome: The Effects of CORM-A1 on Pain and Anxiety-Related Behaviors

Creators

  • 1. Univ Belgrade, Inst Med Physiol Richard Burian, Fac Med, Belgrade 11000, Serbia
  • 2. Univ Belgrade, Inst Histol & Embryol Aleksandar D Kostic, Fac Med, Belgrade 11000, Serbia
  • 3. Univ Belgrade, Univ Clin Ctr Serbia, Clin Urol, Fac Med, Belgrade 11000, Serbia
  • 4. Univ Belgrade, Inst Pathophysiol Ljubodrag Buba Mihailovic, Fac Med, Belgrade 11000, Serbia
  • 5. Univ Belgrade, Univ Clin Ctr Serbia, Clin Endocrinol Diabet & Metab Dis, Fac Med, Belgrade 11000, Serbia
  • 6. Univ Pamukkale, Fac Med, Dept Med Biol, TR-20160 Denizli, Turkiye

Description

Current standard treatments for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a urological disorder with anxiety as a major comorbidity, are limited in success rates. Recent findings revealed the anti-inflammatory and neuroprotective effects of CO-releasing molecules (CO-RMs), but there is a gap in the knowledge on its effects in CP/CPPS. Therefore, the objective of our study was to investigate the potential therapeutic effects of CORM-A1 on the scrotal pain threshold and anxiety-related behaviors in experimental model of CP/CPPS. Adult Wistar albino male rats were randomized to Sham (intraprostatic saline) or CP/CPPS (intraprostatic lambda-carrageenan) groups (n = 12). Half received CORM-A1 (2 mg/kg/day, i.p., days 1-7), others PBS, forming four subgroups (n = 6). The pain threshold (by an electronic von Frey esthesiometer) and anxiety-like behavior (by an open field, elevated plus maze and light/dark test) were assessed; prostates were histologically examined. Carrageenan-induced CP/CPPS caused significant mechanical pain hypersensitivity (p < 0.001), anxiety-like behaviors (p < 0.001-0.05), and histological prostate damage when compared to corresponding Sham groups. CORM-A1 treatment increased pain thresholds (p < 0.001) and improved behavioral outcomes (p < 0.001-0.01) in all ethological tests. These findings indicate that CORM-A1 exerts analgesic and anxiolytic effects in an experimental model of CP/CPPS in rats.

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