Investigation of APOE2 rs7412 and APOA2 rs5082, APOA5 rs662799 and MTHFR rs1801133 Polymorphisms in Diabetic Obese and Non-Obese Diabetic Groups in Turkey

Obesity caused by an abnormal increase in adiposyte, is linked to type 2 diabetes. Diabetes is a metabolic-disease that is caused by insulin-deficiency. Type 2 diabetes is a serious implication of obesity and genetic polymorphisms. Apolipoprotein E2 (APOE2)(rs7412), Apolipoprotein A2 (APOA2) (rs5082), Apolipoprotein A5 (APOA5) (rs662799), Methylenetetrahydrofolate reductase (MTHFR) (rs1801133) polymorphisms which were determined to play role in the development of obesity and diabetes, were evaluated with the RT-qPZR in the study. We included 99 diabetic obese and 99 diabetic non-obese people. We investigated the effect of obesity on variants of all gene polymorphisms in diabetic patients. As a result, APOA2, APOE2 polymorphisms were significant, APOA5, MTHFR polymorphisms were not significant in genotype/allele frequency between groups. APOA2 CC-homozygous carriers had high low-density-lipoprotein-c, glucose, body-mass-index in diabetic-obese patients. APOE2 C-allele carriers had significantly high-Triglyceride and low high-density-lipoprotein versus TT-genotype in non-obese diabetic patients. The present study was first in the Turkey population and evaluates the polymorphisms of genes indicated in diabetic patients.