Published January 1, 2018
| Version v1
Journal article
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Chelating and antioxidant properties of L-Dopa containing tetrapeptide for the treatment of neurodegenerative diseases
Creators
- 1. G Annunzio Univ Chieti Pescara, Dept Pharm, Via Vestini 31, I-66100 Scalo, Chieti, Italy
- 2. Univ Padua, Dept Chem Sci, Via Marzolo 1, I-35131 Padua, Italy
- 3. G Annunzio Univ Chieti Pescara, Dept Med & Aging Sci, Via Vestini 31, I-66100 Scalo, Chieti, Italy
Description
Neurodegenerative diseases share a common pathogenetic mechanism involving aggregation and deposition of misfolded proteins, oxidative stress, metal dyshomeostasis, and glutamate exicitotoxicity, which lead to progressive dysfunction of central nervous system (CNS). A potential strategy to counteract these deleterious events at neuronal level is represented by the employment of a novel class of multi-target therapeutic agents that selectively and simultaneously hit these targets
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