Curcumins-Loaded ZIF-8 Nanoparticles-Embedded Transdermal Polymeric Patches Increase Apoptosis and Reduce Necrosis in a Dose-Dependent Manner in MCF-7 Cells
Creators
- 1. Univ Hlth Sci, Hamidiye Fac Pharm, Dept Pharmacol, Istanbul, Turkiye
- 2. Marmara Univ, Fac Pharm, Dept Pharmacol, Istanbul, Turkiye
- 3. Marmara Univ, Fac Engn, Dept Met & Mat Engn, Istanbul, Turkiye
- 4. TUBITAK Marmara Res Ctr, Mat Inst, Gebze, Kocaeli, Turkiye
- 5. Marmara Univ, Fac Engn, Dept Chem Engn, Istanbul, Turkiye
- 6. UCL, Dept Mech Engn, London, England
Description
Curcumin(Cur)-loaded zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (Cur@ZIF-8 NPs) were produced to increase the anticancer activity of Cur. Cur@ZIF-8 NPs were embedded in polycaprolactone (PCL) fibers as transdermal polymeric patches via a pressured gyration (PG) method to provide controlled release. Cur@ZIF-8 NPs and Cur@ZIF-8 NPs-embedded PCL fibers were characterized for physical, chemical, mechanical, and thermal properties, also biological activities were examined with in vitro tests. Cur@ZIF-8 NPs were produced homogeneously with a size of similar to 200 nm and a zeta potential of similar to-19 mV. Cur had better stability inside Cur@ZIF-8 NPs than its powder form. Cur@ZIF-8 NPs were successfully loaded in PCL fibers with a size of similar to 7 mu m, and Cur@ZIF-8 NPs were dispersed amorphously in fibers. Cur was released in a controlled manner, and its efficiency was increased in the acidic microenvironment that is characteristic of cancer. Cur@ZIF-8 NPs have more bioavailability than powdered Cur and can penetrate the cells to deliver their anticancer effects on MCF-7 human breast cancer cells. Cur@ZIF-8 NPs-embedded transdermal polymeric patches promote apoptosis in MCF-7 cells by reducing necrosis, particularly under acidic conditions. This work presents a release system with synergistic anticancer effects, offering a novel approach for Cur's clinical application in breast cancer through enhanced targeting.
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