The optimisation of caffeic acid reactive extraction by trioctylphosphine oxide using response surface methodology

Caffeic acid is a valuable product due to its wide-ranging utilities. Currently, caffeic acid can be produced via fermentation process using native or engineered microorganisms. The reactive extraction is a prominent technique that is used for the recovery of carboxylic acids. In this work, caffeic acid was recovered by an organophosphate (trioctylphosphine oxide) from its aqueous solution in the presence of different kinds of solvents namely 1-butanol, ethyl propionate, and ethyl methyl ketone. The values of reactive extraction parameters were optimised by Box-Behnken design. 98.19% The maximum extraction efficiency was obtained as 98.19% at the optimum conditions of 0.003 mol kg(-1) caffeic acid concentration, 50% (v/v) trioctylphosphine oxide quantity, and 306.2 K in the presence of 1-butanol as the solvent. Our study is the first ever to examine the reactive extraction of caffeic acid, and therefore very important in modern scientific disciplines.