Published January 1, 2024 | Version v1
Journal article Open

A taste of a toxin paradise:<i> Xenorhabdus</i> and<i> Photorhabdus</i> bacterial secondary metabolites against<i> Aedes</i><i> aegypti</i> larvae and eggs

  • 1. Aydin Adnan Menderes Univ, Fac Sci, Dept Biol, TR-09100 Aydin, Turkiye
  • 2. Adnan Menderes Univ, Kocarli Vocat Sch, Dept Plant & Anim Prod, TR-09100 Aydin, Turkiye
  • 3. Adnan Menderes Univ, Recombinant DNA & Recombinant Prot Ctr, TR-09100 Aydin, Turkiye
  • 4. Adnan Menderes Univ, Aydin Hlth Serv Vocat Sch, TR-09100 Aydin, Turkiye

Description

Aedes-transmitted arboviral infections such as Dengue, Yellow Fever, Zika and Chikungunya are increasing public health problems. Xenorhabdus and Photorhabdus bacteria are promising sources of effective compounds with important biological activities. This study investigated the effects of cell-free supernatants of X. szentirmaii, X. cabanillasii and P. kayaii against Ae. aegypti eggs and larvae and identified the bioactive larvicidal compound in X. szentirmaii using The EasyPACId method. Among the three tested bacterial species, X. cabanillasii exhibited the highest (96%) egg hatching inhibition and larvicidal activity (100% mortality), whereas P. kayaii was the least effective species in our study. EasyPACId method revealed that bioactive larvicidal compound in the bacterial supernatant was fabclavine. Fabclavines obtained from promoter exchange mutants of different bacterial species such as X. cabanillasii, X. budapestensis, X. indica, X. szentirmaii, X. hominckii and X. stockiae were effective against mosquito larvae. Results show that these bacterial metabolites have potential to be used in integrated pest management (IPM) programmes of mosquitoes.

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