Published January 1, 2010
| Version v1
Journal article
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Cytotoxicity of Natural Compounds Isolated from the Seeds of Garcinia afzelii
Creators
- 1. Univ Yaounde I, Dept Organ Chem, Fac Sci, Yaounde, Cameroon
- 2. Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
- 3. Univ Alexandria, Dept Chem, Fac Sci, Alexandria 21321, Egypt
Description
The new compounds guttiferone O (1) and 3-methoxycheffouxanthone (2) have been isolated from the seeds of Garcinia afzelii Engl., together with nine known compounds: 2-hydroxy-1,7-dimethoxyxanthone (3), smeathxanthone A (4), 1,5-dihydroxyxanthone (5), 1,6-dihydroxy-5-methoxyxanthone (6), cheffouxanthone (7), 1,3,5-trihydroxyxanthone (8), smeathxanthone B (9), isoxanthochymol (10) and guttiferone E (11). Their structures were elucidated by means of 1D and 2D-NMR techniques. All the isolates showed high cytotoxic activity and were found inactive when tested against HIV and influenza viruses.
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