Phenylalanine: Amino Acid Metal Non-Enzymatic Electrochemical Voltammetric Sensors

This study presents a comparative analysis of non-enzymatic electrochemical voltammetric sensors, utilizing phenylalanine amino acid metal complexes (M: Ni, Zn, and Co) Polyaniline (PANI) nanocomposites (NCs). The PANI: Zn(Phala)2 NCs-based sensor detected dopamine (DA) with a sensitivity of 101.18 mu A mu M-1 cm(-2). The limit of detection (LOD) for the PANI: Zn(Phala)(2) NCs-based sensor was calculated as 0.391 mu M. This exceptional sensitivity makes the PANI: Zn(Phala)(2) NCs-based sensor highly promising for potential integration into biomedical test kits. To gain deeper insights into the structural properties of the PANI NCs, scanning electron microscopy (SEM), artificial-intelligence-based SEM, and Fourier transform infrared spectroscopy (FTIR) were employed for characterization. FTIR characterization provided insights into the functional groups of the NCs. The results of this comparative investigation a significant advancement in the field of PANI-based electrochemical sensors designed for DA sensing. The PANI: Zn(Phala)(2) NCs-based sensor show great promise for a range of advanced sensing applications. The Z value of the PANI: Zn(Phala)(2) NCs-based sensor is the lowest among the tested materials, indicating that the conductivity of the PANI: Zn(Phala)(2) layer is higher than that of other active layers. Consequently, the PANI: Zn(Phala)(2) NCs-based sensor achieved higher sensitivity in DA detection. (c) 2024 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited. All rights, including for text and data mining, AI training, and similar technologies, are reserved.