Published January 1, 2024
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Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular modeling studies of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety
Creators
- 1. Istanbul Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34116 Istanbul, Turkiye
- 2. İstanbul Univ, Fac Pharm, Dept Biochem, TR-34116 Istanbul, Turkiye
Description
Herein, we report the in vitro Acetylcholinesterase (AChE) inhibitory activities of imidazo[2,1-b]thiazole derivatives bearing thiosemicarbazide moiety. The compounds were characterized by diverse spectral methods and reported by our research team previously. As a novelty we conducted in vitro AChE inhibitory activities of the title compounds and performed in silico studies to provide insight related to activity mechanism of the compounds. Compound 4f displayed the best biological activity within our compounds with 69.92% enzyme inhibition value (at a final concentration of 0.08 mg/mL) and 0.0245 mg/mL IC50 value.
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