ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
Oluşturanlar
- 1. Univ Bogazici, Dept Mol Biol & Genet, Bebek, Istanbul TR-34342, Turkiye
- 2. Univ Liege, Lab Mol Pharmacol, GIGA Mol Biol Dis, Liege, Belgium
- 3. Univ Paris Cite, Inst Cochin, CNRS, INSERM, Paris, France
- 4. Natl Ctr Sci Res Demokritos, Inst Biosci & Applicat, Lab Cellular Signalling & Mol Pharmacol, Athens, Greece
- 5. Karolinska Inst, Div Clin Geriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
- 6. Philipps Univ Marburg, Dept Pharmaceut Chem, Marburg, Germany
- 7. Univ Leipzig, Med Fac, Div Gen Biochem, Rudolf Schonheimer Inst Biochem, Leipzig, Germany
Açıklama
G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important drug targets. This overview emphasises the GPCRs of the nervous system, which are the research focus of the members of ERNEST COST action (CA18133) working group 'Biological roles of signal transduction'. First, the (patho)physiological role of the nervous system GPCRs in the modulation of synapse function is discussed. We then debate the (patho)physiology and pharmacology of opioid, acetylcholine, chemokine, melatonin and adhesion GPCRs in the nervous system. Finally, we address the orphan GPCRs, their implication in the nervous system function and disease, and the challenges that need to be addressed to deorphanize them.
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